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Treatment considerations include: Concurrent folate supplementation if deficient (never give folate alone, as it may precipitate neurological deterioration) Potassium monitoring during initial treatment in severe anaemia or at-risk patients (e.g., those with heart failure) Response assessment: reticulocyte count peaks at 57 days, haemoglobin normalises within 68 weeks Neurological symptoms may take 612 months to improve and may not fully resolve Patients should be advised that treatment for pernicious anaemia or post-surgical deficiency is lifelong

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It therefore represents an ideal target for candidate drug therapies as its modulation will undoubtedly have an impact on disease progression

Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity

In vitro biostability of M-CuP and D-CuP against Proteinase K 1 mM D-CuP and 2 mM M-CuP aqueous solutions (1 mL) were incubated separately with Proteinase K (10 U mL 1 , 100 L) at 37 C for 0, 1, 2 and 4 h